







Feeling sluggish, unfocused, or overwhelmed?
These struggles often stem from imbalances in your body’s ability to produce the vital neurotransmitters responsible for mental clarity, energy, and emotional well-being. Factors like poor diet, stress, and even genetics can disrupt these processes, leading to brain fog, low energy, anxiety, and feelings of depression.
Thankfully, there’s a solution! Our L-Methylfolate 5-MTHF supplement is scientifically formulated to restore balance and help you feel your best every day.
L-Methylfolate is the active, bioavailable form of folate that supports your body’s natural ability to produce serotonin, dopamine, and norepinephrine—key neurotransmitters for energy, focus, and mood.

Mental Clarity All Day Long
Unlike any other supplement on the market, our L-Methylfolate 5-MTHF formula goes beyond surface-level benefits to address the root causes of brain fog, fatigue, and low mood. The active form of folate in our product works deep within your body to support neurotransmitter production, improving mental clarity and lifting your mood for hours.
L-Methylfolate also boosts natural energy levels, helping you feel more motivated and productive throughout the day. Additionally, it plays a crucial role in reducing stress and anxiety by promoting a balanced and healthier nervous system. Together, these benefits deliver a sense of clarity and focus that ordinary supplements just can’t match.

Targeted Support for Clearer Thinking and Balanced Energy
Our L-Methylfolate 5-MTHF supplement is crafted with bioavailable, science-backed ingredients to support mental clarity, mood, and energy. L-Methylfolate works at the root level to enhance neurotransmitter production, promoting better focus, reduced brain fog, and emotional balance.
This active form of folate aids in the production of serotonin, dopamine, and norepinephrine—key neurotransmitters that uplift mood and fight anxiety. It also supports energy metabolism at the cellular level, helping you feel more motivated and productive. Together, these benefits create a powerful foundation for mental clarity, calmness, and confidence.

Read about the clinical test
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Overview
Overview
We conducted a 3rd-party test to evaluate the effectiveness of our L-Methylfolate supplement on neurotransmitter activity levels, which are essential for brain health, mood, and energy.
Why Test for Neurotransmitters?
Why Test for Neurotransmitters?
Neurotransmitters like serotonin, dopamine, and norepinephrine play a crucial role in regulating mental clarity, mood, and energy levels. Measuring these levels allows us to directly assess how well our supplement supports these vital functions.
Results
Results
Over a 90-day period:
- Participants taking L-Methylfolate showed a 7.9% increase in neurotransmitter activity.
- Participants in the placebo group saw only a 1.1% increase.
What This Shows
What This Shows
These results highlight that our L-Methylfolate supplement works effectively at the root level to boost neurotransmitter activity, helping to improve mental clarity, uplift mood, and enhance energy naturally.
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Customer Study Results
95%
experienced significant decrease in stress and anxiety
92%
saw significant increase in mental sharpness & focus
88%
saw a natural boost in overall mood & energy levels
*Results based on a random selection of 2,000 customer surveys
See why Purifi Is Loved by Thousands
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FAQs
What is L-Methylfolate, and how does it work?
What is L-Methylfolate, and how does it work?
L-Methylfolate is the bioactive form of folate (Vitamin B9), which your body uses to produce essential neurotransmitters like serotonin, dopamine, and norepinephrine. These neurotransmitters help improve mood, mental clarity, focus, and energy. Unlike synthetic folic acid, L-Methylfolate is already in its active form, making it easier for your body to absorb and use.
Who can benefit from this product?
Who can benefit from this product?
Anyone looking to improve mental clarity, reduce brain fog, enhance focus, lift their mood, or manage anxiety may benefit. It’s particularly effective for individuals with MTHFR gene mutations who struggle to process synthetic folic acid.
How long does it take to see results?
How long does it take to see results?
Most people begin to notice improvements in mental clarity, energy, and mood within 2-4 weeks of consistent use. For optimal results, we recommend using the product for at least 90 days.
Are there any side effects?
Are there any side effects?
L-Methylfolate is generally well-tolerated and has minimal to no side effects when taken as directed. If you have a medical condition or are taking medications, consult your healthcare provider before use.
How do I take this supplement?
How do I take this supplement?
Take one capsule daily with a meal, or as directed by your healthcare professional. This ensures proper absorption and maximum effectiveness.
Is this product safe for long-term use?
Is this product safe for long-term use?
Yes, L-Methylfolate is safe for long-term use and can be taken daily to support brain health, mood, and energy.
Can I take this with other medications?
Can I take this with other medications?
L-Methylfolate is generally safe, but it’s always best to consult your doctor if you’re taking medications for depression, anxiety, or other health conditions to avoid potential interactions.
Is this product gluten-free and non-GMO?
Is this product gluten-free and non-GMO?
Yes, our L-Methylfolate supplement is gluten-free, non-GMO, and made with the highest quality ingredients.
Can this help with depression or anxiety?
Can this help with depression or anxiety?
L-Methylfolate supports the production of neurotransmitters like serotonin, which are often imbalanced in individuals with depression or anxiety. While it can help, it is not a substitute for prescribed medications and should be used as part of a broader health strategy.
Is this supplement suitable for vegetarians or vegans?
Is this supplement suitable for vegetarians or vegans?
Yes, our product is 100% vegan and free from any animal-derived ingredients.